Dr. Diptiman Choudhury

Associate Professor


Cell Biology, Wound healing, Anti cancer and Anthelminthic Drug development, Drug delivery system Protein-nanoparticle interactions, Biosensors




Cell Biology, Wound healing, Anti cancer and Anthelminthic Drug development, Drug delivery system Protein-nanoparticle interactions, Biosensors



Dr. Diptiman Choudhury

Associate Professor,1 Team Leader of BioX 2

1; School of Chemistry and Biochemistry,

2; TIET-VT (USA) Center for Excellence in Material Sciences (CEEMS),

Thapar Institute of Engineering and Technology, Patiala – 147004, Punjab

Email: diptiman@thapar.edu and diptiman.choudhury@gmail.com

Contact No.: +91-8196949843


Research Interests / Specialization:  Cancer Biology; Anthelminthic Drug development and delivery; Wound healing and Inflammatory Regulation; Biosensors.


Education and Training:


  • 2012-2015: Post Doctoral Scientist, Cedars Sinai Medical Center, Los Angeles, CA, USA.
  • 2006-2012: Ph.D. in Biotechnology, University of Calcutta, Kolkata, India.
  • 2004-2006: M.Sc. Biotechnology; University of Calcutta, Kolkata.
  • 2001-2004: B.Sc. Microbiology (Hons.), Rastraguru Surendranath College, Barrackpore, Kolkata,


Professional Affiliations:


  • Associate Professor (1st July 2022-Onwards)

School of Chemistry and Biochemistry, Thapar University, Patiala-147004, India

  • Assistant Professor-III (2nd May 2018- 15th May 2022 )

School of Chemistry and Biochemistry, Thapar University, Patiala-147004, India

  • Assistant Professor-II (1st February 2017-1st May 2018)

School of Chemistry and Biochemistry, Thapar University, Patiala-147004, India

  • Assistant Professor-I (18th August 2015 – 31st January 2017)

School of Chemistry and Biochemistry, Thapar University, Patiala-147004, India

  • Postdoctoral Scientist (10th July 2012 – 10th August 2015)

Department of Medicine, Cedars Sinai Medical Center, Los Angeles, California, USA.

Area of research:  Understanding of Cancer Microenvironment and Development of Early detection tool for Prostate Cancer.

  • Doctoral (Ph.D.) work (29th August 2006 – 4th July 2012)

Department of Biotechnology, University of Calcutta, Kolkata, India.

Advisor: Dr. Gopal Chakrabarti

Title of thesis: "Study of antimitotic activity of gold nanoparticles, apigenin and ginger aqueous extract by targeting tubulin-microtubule system."

Area of research: Anticancer drug development, Cell Biology, Drug-protein interactions.


Teaching Activities (at Thapar Institute of Engineering and Technology):


M.Sc. Biochemistry/ Chemistry/ Ph.D. course work

Bio-analytical Chemistry (PBC-104),

Chemical Biology (PCY-108)

Immunology and Immunotherapy (PBT210)

Cellular Metabolism (PBC-220)

Pharmaceutical and Medicinal Chemistry (PCY-220)

Signal Transduction and Endocrinology (PBC-311)

Nano-Biomaterials, Bio-Sensing and Biomedical Application (PBC-312)


Applied Chemistry (UCB008)


Research Work



Post-doctoral Research



Ph.D. Supervision



M.Sc. Dessertation Supervision



Summer Research Supervision



Resaerch Supervision:


List of Publications (SCI Journals):


  1. Electro-oxidation Treatment of Sewage Water Using Mixed Metal Oxide Anodes for Microbial Decontamination. P. Chndra, A. Verma,* D. Choudhury* J. Water Process. Eng. 2022 ( just Accpeted),        (Impact factor: 5.46)
  2. Bacterioboat, a novel tool to increase the half-life period of the orally administered drug. P. Kaur, S. Ghosh, A. Bhowmick, K. Gadhave, S. Datta, A. Ghosh, N Garg, R.L. Mahajan, B. Basu*, D. Choudhury* Sci. Adv. 2022 8(10) eabh1419  (Impact Factor: 14.136)
  3. Synthesis and photobiological applications of naphthalimide–benzothiazole conjugates: cytotoxicity and topoisomerase IIα inhibition. I. Singh, V. Laxmi, D. Choudhury, K. Paul*. RSC Advances 2022 12(1): 483-497  (Impact Factor 3.070)
  4. Protection of lead-induced cytotoxicity using paramagnetic Nickel-Insulin quantum clusters. D. Sharda, K. Attri, P. Kaur, D. Choudhury*. RSC Advances 2021 11: 24656-24668.             (Impact Factor 3.070)
  5. COVID-19 pandemic in India: Chronological comparision of the regional heterogenicity in the pandemic progression and gaps in mitigation strategies. S. Datta, N.K. Chakroborty, D. Sharda, K. Attri, D. Choudhury*. J. Clin. Trials 2021, 11: S13:004                (Impact Factor 2.76)
  6. Probing the interaction of glutathione with different shapes of silver nanoparticles by optical spectroscopy. P. Kaur, K Gadhuve, N. Garg, D. Deb*, D. Choudhury* Mater. Today Commun. 2021 26(1), 102137 (Impact Factor 3.31)
  7. Bone marrow mesenchymal stem cells interact with head and neck squamous cell carcinoma cells to promote cancer progression and drug resistance. C. Liu, S. Billet, D. Choudhury, R. Cheng, S. Haldar, A. Fernandez, S. Biondi, Z. Liu, H. Zhou, N.A. Bhowmick* Neoplasia 2021, 23(1):  118-128  (Impact Factor 5.715)
  8. Functionality of Receptor Targeted Zinc-Insulin Quantum Clusters in skin tissue augmentation and bioimaging. P Kaur, D. Choudhury* J Drug Target 2021, 29(5): 541-550 (Impact Factor 3.380)
  9. Biomedical evaluation of Lansium parasiticum extract protected silver nanoparticles against Haemonchus contortus, a parasitic worm. V. Goel, L. D. Singla,* D, Choudhury*, Front. Mol. Biosci. 2020, 7, 595646           (Impact Factor 4.62)
  10. Cuminaldehyde induces oxidative stress-mediated physical damage and death of Haemonchus contortus. V. Goel, L. D. Singla,* D, Choudhury* Biomed Pharmacother 2020, 130, 110411.  (Impact Factor: 6.529)
  11. Insulin-Copper Quantum Clusters Preparation and Receptor Targeted Bioimaging. P. Kaur, S. Sharma, S. D. Choudhury, D. Singh, S. Sharma, K. Gadhave, N. Garg, D. Choudhury* Colloid Surface B 2020, 188, 110785                (Impact factor 5.268)
  12. The innovative approach of in-situ fixed mode dual effect (photocatalysis and photo-Fenton) for the degradation of ofloxacin. K. Sharma, S. Talwar, A.K. Verma,* D. Choudhury, B. Mansouri, Korean J. Chem. Eng. 2020, 37, 350–357         (Impact Factor: 2.690)
  13. Biocatalytic AzaMichael Addition of Aromatic Amines to Enone Using αAmylase in Water. S. Datt, V. Goel, N. Garg, D. Choudhury, D. Mallik, V. Tyagi. Adv. Synth. Catal. 2020, 362 (4), 858-866    (Impact factor 5.42)
  14. Periodontal inflammation recruits distant metastatic breast cancer cells by increasing myeloid-derived suppressor cells. R. Cheng, S. Billet, C. Liu, S. Haldar, D. Choudhury, M. Tripathi, M. Hav, A. Merchant, T. Hu, H. Huang, H.  Zhou,* N.A. Bhowmick* Nature Oncogene 2020, 39,  1543–1556             (Impact Factor: 9.867)
  15. Al3+ induced hydrolysis of rhodamine-based Schiff-base: Applications in cell imaging and ensemble as CN sensor in 100% aqueous medium. R. Mehta, P. Kaur, D. Choudhury, K. Paul, V. Luxami J. Photochem. Photobiol. A, 2019, 380, 111851             (Impact Factor: 4.291)
  16. Insulin Promotes Wound Healing by Inactivating NFkβP50/P65 and Activating Protein and Lipid Biosynthesis and alternating Pro/Anti-inflammatory Cytokines Dynamics." P. Kaur, D. Choudhury* Biomol. Concepts, 2019, 10(1):11-24        (Impact Factor: 3.25).
  17. Autophagy inhibition with chloroquine reverts paclitaxel resistance and attenuates metastatic potential in human nonsmall lung adenocarcinoma A549 cells via ROS mediated modulation of β-catenin pathway. S. Datta, D. Choudhury, A. Das, D.D. Mukherjee, M. Dasgupta, S.Bandopadhyay, G. Chakrabarti* Apoptosis. 2019, 24(5-6): 414-433   (Impact Factor: 4.677)
  18. Novel nano-insulin formulation modulates cytokine secretion and remodeling to accelerate diabetic wound healing. P. Kaur, A.K. Sharma, D. Nag, A. Das, S.Datta, A. Ganguli, V. Goel, S. Rajput, G. Chakrabarti, B. Basu, D. Choudhury* Nanomedicine: NBM. 2019, 15(1), 47-57.        (Impact Factor: 6.458)
  19. Effective removal of metal ions from aqueous solution by mesoporous MnO2 and TiO2 monoliths: Kinetic and equilibrium modeling. M. Sharma, D.  Choudhury, S. Hazra, S. Basu*, J. Alloys. Compd. 2018, 720, 221-229.  (Impact Factor: 5.361)
  20. Variation of Surface Area of Silica Monoliths by Controlling Ionic Character/Chain Length of Surfactants and Polymers. M. Sharma, A. Mishra, A. Mehta, D. Choudhury, and S. Basu*, Mater. Lett. 2017, 194, 213-216.                       (Impact Factor: 3.423)
  21. Paclitaxel resistance development is associated with biphasic changes in ROS, mitochondrial membrane potential and autophagy with elevated energy production capacity in lung cancer cells: A chronological study. S. Datta, D. Choudhury, A. Das, D.D. Mukherjee, N. Das, S.S. Roy, and G. Chakrabarti*, Tumor Biol. 2017, 39(2), 1-14.   (Impact Factor: 3.597)
  22. Effect of surfactants on the structure and adsorption efficiency of hydroxyapatite nanorods. M. Sharma, A. Mishra, A. Mehta, D. Choudhury, and S. Basu* J. Nanosci. Nanotechnol. 2017, 17, 1-11.      (Impact Factor: 1.354)
  23. Enhanced catalytic and antibacterial activity of nanocasted mesoporous silver monoliths: kinetic and thermodynamic studies. M. Sharma, A. Mehta, A. Mishra, D. Choudhury and S. Basu*, J. Sol-Gel Sci. Technol. 2017, 81, 704-710.   (Impact Factor: 2.008)
  24. Gingival fibroblasts resist apoptosis in response to oxidative stress in a model of periodontal diseases. R. Chang, D. Choudhury, C. Liu, S. Billet, T. Hu, and N.A. Bhowmick*, CD Discovery 2015, 1, 15046           (Impact Factor: 4.53).
  25. Inflammation and pyroptosis mediate muscle expansion in an IL-1β; -dependent manner. S. Haldar, C. Dru, D. Choudhury, A. Fernandez, S. Biondi, Z. Liu, K. Shimada, M. Arditi, N.A. BhowmickJ. Biol. Chem. 2015, 290(10), 6574-6583.       (Impact Factor: 5.157)
  26. Identification of a novel E-box binding PI polyamide inhibiting MYC-driven cell-proliferation. R. Mishra, T. Watanabe, M. Kimura, N. Koshikawa, M. Ikeda, S. Uekusa, H. Kawashima, X. Wang, J. Igarashi, D. Choudhury, C. Grandori, C. Kemp, M. Ohira, N. Verma, Y. Kobayashi, J. Takeuchi, T. Koshinaga, N. Nemoto, N. Fukuda, M. Soma, T. Kusafuka, K. Fujiwara, H. Nagase* Cancer Sci. 2015, 106(4), 421-429.                (Impact Factor: 6.716)
  27. Inhibition of autophagy by chloroquine potentiates synergistically anticancer property of artemisinin by promoting ROS dependent apoptosis. A. Ganguli, D. Choudhury, S. Datta, S. Bhattacharya, G. Chakrabarti* Biochimie 2014, 107(B), 338-349.              (Impact Factor: 4.079)
  28. 2,4-Dichlorophenoxy acetic acid-induced toxicity in lung cells by disrupting tubulin-microtubule network. A. Ganguli,# D. Choudhury,# G. Chakrabarti*, Toxicol. Res. 2014, 3, 118-130.         (Impact Factor: 3.524) [#= equal contribution].
  29. Unprecedented inhibition of tubulin polymerization directed by gold nanoparticles inducing cell cycle arrest and apoptosis. D. Choudhury, P.L. Xavier, K. Chaudhari, R. John, A.K. Dasgupta, T. Pradeep*, G. Chakrabarti*, Nanoscale 2013, 5(10), 4476-4489. (Impact Factor: 7.79)
  30. Apigenin shows synergistic anticancer activity with curcumin by binding at different sites of tubulin." D. Choudhury, A. Ganguli, D.G. Dostidar, B.R. Acharya, A. Das, G. Chakrabarti* Biochimie 2013,  95(6), 1297-1309.     (Impact Factor: 4.079)
  31. Acenaphthenequinone induces cell cycle arrest and mitochondrial apoptosis via disruption of cellular microtubule. A. Das, D. Choudhury, S. Chakrabarty, A. Bhattacharyya, G. Chakrabarti* Toxicol. Res. 2012, 1, 171-185.            (Impact Factor: 3.524)            [Cover page article]
  32. The microtubule depolymerizing agent naphthazarin induces both apoptosis and autophagy in A549 lung cancer cells.  B.A. Acharya, S. Bhattacharyya, D. Choudhury,  G. Chakrabarti*  Apoptosis 2011, 16(9), 924-939.               (Impact Factor: 4.677)
  33. A complex of Co(II) with 2-hydroxyphenyl-azo-2'-naphthol (HPAN) is far less cytotoxic than the parent compound on A549-lung carcinoma and peripheral blood mononuclear cells: Reasons for reduction in cytotoxicity. T. Deb, D. Choudhury, P.S. Guin, M.B. Sahaq, G. Chakrabarti, S. Das* Chem. Biol. Interact. 2011, 189(3), 206-214.                  (Impact Factor: 5.192)
  34. 1,4-Benzoquinone (PBQ) induced toxicity in lung epithelial cells is mediated by the disruption of the microtubule network and activation of caspase-3. A. Das, S. Chakrabarty, D. Choudhury, G. Chakrabarti* Chem. Res. Toxicol. 2010, 23, 1054-1066.            (Impact Factor: 3.739)
  35. Aqueous extract of ginger shows anti-proliferative activity through disruption of microtubule network of cancer cells. D. Choudhury, A. Das, A. Bhattacharya, G. Chakrabarti*  Food Chem. Toxicol. 2010, 48(10), 2872-2880.          (Impact Factor: 6.023)
  36. Vitamin K3 disrupts the microtubule networks by binding to tubulin: a novel mechanism of its antiproliferative activity. B.R. Acharya, D. Choudhury, A. Das, G. Chakrabarti* Biochemistry 2009, 48(29), 6963-6974.       (Impact Factor: 3.162)


Conference Publications:

  1. Gut microflora mediated novel oral drug delivery system. P. Kaur, D. Choudhury* Cancer Res. 2021, 81 (13S) 310  (Impact Factor 12.701)
  2. Use of methionine metabolites in predicting recurrent prostate cancer affordably." D. Choudhury, S. Haldar, N.A. Bhowmick* Cancer Res. 2014, 74 (S19), 2868.          (Impact Factor: 12.701)
  3. Microtubule-Destabilizing Agent Arrests A549 Cell Cycle in G2/m and Induces Apoptosis by Inhibiting Pi3K/akt Signalling and Enhancing Nf-Kb Activation B.R. Acharya, D. Choudhury, g. Chakrabarti* Annals of Oncology 2010, 21, 37.



  1. Targeted drug delivery using Beeswax derived Albendazole-Loaded Solid Lipid Nanoparticles in Haemonchus contortus, an albendazole tolerant nematode. S. Sharma, V. Goel, P. kaur, K. Gadhube, N. Garg, L.D. Singla, D. Choudhury* bioRxiv 2021, doi: 10.1101/2021.07.24.453620.
  2. Targeting the nervous system of the parasitic worm, Haemonchus contortus, with quercetin. V. Goel, N.K. Chakroborty, L.D. Singla, D. Choudhury* bioRxiv 2021, doi: 10.1101/2021.07.11.451932.


List of Manuscripts Communicated


  1. Hesperidin attenuates cell viability and metastatic potential of MCF7 breast cancer cell lines by targeting and stabilizing its cMYC G quadruplex. S. Datta, P. Kumar, R. Giri, D. Choudhury*
  2. Targeting the nervous system of the parasitic worm, Haemonchus contortus, with quercetin. V. Goel, N. K. Chakroborty, S. Sharma, L. D. Singla, D. Choudhury*.
  3. Targeted drug delivery using beewax derived Albendazole loaded solid lipid nanoparticles in Haemonchous  contortus, an albendazole  tolerate nematode. S. Sharma, V. Goel, P. Kaur, K. Gadhave, N. Garg, L. D. Singla, D. Choudhury.*
  4. Terpins for Gastric Cancer Treatment. K. Attri, D. Sharda, B. Chudasama, R.L. Mahajan, D. Choudhury*  (Review)
  5. Deciphering the Mechanism of Inner Filter Effect on Heteroatom Doped Carbon dots-MnO2 Nanoprobe for Selective Detection of Glutathione and Intracellular Imaging. N. Sohai, S. Sharma, D. Choudhury, B. Maity, B. Basu.*
  6. Nutraceuticals and their derivatives with G-quadruplex stabilizing potential attenuates cancer progression by hindering oncogenic transcription and replication. S. Datta, D. Choudhury*
  7. Nanomedicine as future medicine for managing parasitic worm infections. H. Kaur, L.D. Singla,* D. Choudhury* (Review)


List of Manuscripts under Preparation:


  1. Sensing of mitochondrial reactive sulfide species with napthalamide-phenanthroimidazol conjugate. S. Sharma, I. Singh, K. Paul, D. Choudhury*
  2. Synthesis of azide based napthalic anhydride for sensing of intercellular reactive sulfide species.S. Gupta, S. Sharma, K. Pual*, D. Choudhury*
  3. Synthesis of benzothiazole based fluorescent Schiff base for the specific detection of intercellular reactive chloride species. A. Sharma, S. Sharma, D. Choudhury, K. Paul, V. Laxmi*
  4. Tannins protected green synthesized nanoformulations for wound care. D. Sharda, K. Attri, D. Choudhury* (Review)
  5. Role of cytokines in autophagy targeted cancer therapy. S. Datta, D. Choudhury*, (Review)





  1. "Universal delivery system for drugs/molecules of choice using live microbes and method thereof" D. Choudhury and P. Kaur (2019) Indian Patent No. 201911027084 (published)
  2. “Device, system and method for cancer prognosis and uses thereof”. N.A. Bhowmick, D. Choudhury, M.J. Baker, M.S. Drlik, B. Hansen and A. Bhowmick, (2016) International Patent No. PCT/US2016/017486. (published)
  3. “Methionine metabolites predict aggressive cancer progression”. N.A. Bhowmick and D. Choudhury, (2013) International Patent No. PCT/US2013/054415. (published)


Book Chapters (Published):


  1. CHAPTER TITLE: Modulation of Inflammatory dynamics by insulin to promote wound recovery of diabetic ulcers. BOOK TITLE: Wound Healing. AUTHORS: P. Kaur and D. Choudhury* Publisher: IntechOpen, London, UK. Publication Year: 2020. doi: 10.5772/intechopen.92096
  2. CHAPTER TITLE: Novel Nano Insulin Formulation Modulates Cytokine Secretion and Remodelling to Accelerate Diabetic Wound Healing. Chapter.ID_63249, AUTHORS: P. Kaur and D Choudhury* BOOK TITLE: Progress and Prospectus in Nanoscience Today. PUBLISHERS: Nova Science Publishers, NY, USA, Publication Year: 2020. ISBN: 987-1-53617-292-8
  3. CHAPTER TITLE: Traditional Medicine: Stability and Pharmacokinetic issue, AUTHORS: P. Kaur, S. Sharma, and D Choudhury*   BOOK TITLE: Evidence-Based Validation of Traditional Medicines, PUBLISHERS: Springer Nature, London, UK Publication Year: 2020. doi: 10.1007/978-981-15-8127-4_33

Book Chapters (Communicated)

  1. CHAPTER TITLE: Regulation of cytokines in wound healing by silk fibroin. Authors: D. Sharda, K. Attri, D. Choudhury* BOOK TITLE: Silk fibroine: Advances in Application and Research, PUBLISHERS: Nova Sciences USA.
  2. CHAPTER TITLE: Future research directions of antimicrobial wound dressings. Authors: D. Sharda, K. Attri, D. Choudhury* BOOK TITLE: Antimicrobial Dressings: The Wound Care Applications PUBLISHERS: Elsevire.

Oral and Poster Presentations:


  1. 2020: Oral-Webinar; Guru Nanak Institute of Pharmaceutical Science and Technology, May-2020
  2. 2019: Oral; BE Material Sciences 2019; Brussels, Belgium
  3. 2014: Poster; Annual meeting of American Association for Cancer Research -2014, San Diego. California, USA.
  4. 2012: Poster; International conference on nanoscience and technology-2012, Hyderabad, India.
  5. 2010: Poster; Nanotech India-2010, an international conference, Kochi, India, November.
  6. 2010: Oral; National Science day conference-2010, Jadavpur University, Kolkata, India.
  7. 2007: Poster; 2nd international symposium on translational Research at Lonawala, India.


Awards / Honors / Fellowships:


  1. 2018: Institute Performance Award 2017, TIET, Patiala, Punjab.
  2. 2012: Young investigator award, ICONSAT 2012, Hyderabad, India.
  3. 2010: International travel award; DST, India,
  4. 2010: International Travel ward; CSIR, India.
  5. 2010: Senior Research Fellowship (SRF), Independent-CSIR.             
  6. 2009: Junior Research Fellowship (JRF), CSIR-NET.
  7. 2007: Lectureship (LS), CSIR-NET.
  8. 2006: Junior Research Fellowship (JRF), DAE/BRNS sponsored project.
  9. 2006: Graduate aptitude test in engineering (GATE), Life Sciences.


Sponsored Research Projects:

As Principal Investigator

  1. Development of Cross-contamination-free portable suction assembly for airways clearance in mechanically ventilated patients. ICMR-Govt of India, 22.23 lakhs, 2022-2024 (Fund awaited)
  2. "Treatment of Gastric Cancer by Activation of Natural Immunity using Helicobacter pylori coated with Iron-oxide Nanoparticles: in silico, in vitro, and in vivo approaches" CEEMS-TOP Project, Rs. 25.10 Lakhs, 2020-2023. (Ongoing)
  3. “Development of high-end protein-rich animal feed from Jellyfish and standardization of industrial-scale production.” CEEMS-TOP Project Rs. 0.50 Lakhs, 2021-2023. (Ongoing)
  4. "Encapsulation of Mesoporous Carbohydrate Nanoparticles on Intestinal Microflora Cell Surface for Enhancement of Drug Effectiveness" DST-SERB, 43.12 lakhs, 2017-2020. (Completed)
  5. "Exploration of Indian Pteridophytes to fight against lung cancer" Seed Money Grant, Thapar University, 4.95 lakhs, 2016-2018. (Completed)

As Co-Principal Investigator

  1. Design & Development of microwave-based imaging and hyperthermia systems, for diagnosis & treatment of Skin cancer respectively, and Testing the prototype in 2-D and 3-D organotypic skin epithelial carcinoma model.” ICMR-Govt of India. 63.00 lakhs, 2022-2025. (Fund awaited)
  2. “COVID pandemic management based on real-time detection of airborne viral load in hospitals.” DBT-Govt. of India. Rs. 42.22 Lakhs, 2020-2021. (Completed)
  3. Design and development of graphene derived antimicrobial composite system to resist air and water-borne infection in under-developed areas of India. CEEMS-TOP Project, Rs. 9.2 Lakhs, 2021-2024 (Ongoing)


Other Professional Activities:


  1. Member of American Association of Cancer Research.
  2. Guest Editor of special addition "Nanomedicine and Neglected Tropical Diseases" by Frontiers in Molecular Biosciences. Impact Factor 4.6
  3. AssociateEditor of Molecular Diagnostics and Therapeutics” " by Frontiers in Molecular Biosciences. Impact Factor 4.62
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