Dr. Kamaldeep Paul

Professor

Specialization

Synthetic Organic and Medicinal Chemistry, Supramolecular Chemistry

Email

kpaul@thapar.edu, kamal.paul2001@gmail.com

Specialization

Synthetic Organic and Medicinal Chemistry, Supramolecular Chemistry

Email

kpaul@thapar.edu, kamal.paul2001@gmail.com

Scopus Citations: >2600; h-index: 29 

Fields of Research

  1. C-H functionalization-based synthesis of biological functionalized moieties.
  2. Multiple step palladium and ruthenium catalyzed synthesis of various heterocyclic compounds.
  3. Design, synthesis and evaluation of biological active heterocyclic compounds as anticancer and antimicrobial agents
  4. Design and synthesis of supramolecular materials and their applications in molecular electronic materials

Academic Record

Ph.D., Organic and Medicinal Chemistry, 2001-2006, Guru Nanak Dev University, Amritsar, Punjab, India,

Thesis title: “Synthesis and Structure-Activity-Relationship Studies of Pyrazole and Uracil Based Multidrug Resistance Modulators”

Supervisor: Prof. Palwinder Singh

M.Sc. (Applied Chemistry), Ist Class, 65% marks, 1998-2000, Guru Nanak Dev University, Amritsar, Punjab, India

Thesis title: “Chemical Oxygen Demand (COD) Reduction from Aqueous Dye Solutions Using Saw Dust Ash as an Adsorbent”

Supervisor: Prof. Sumanjit Kaur

B. Sc. (Medical), Ist Class, 65% marks, 1995-1998, D.A.V. College, Amritsar, Punjab, India

Details of professional training and Research Experience:

Postdoctoral Fellow: BK21 fellowship, Department of Chemistry and Medicinal Chemistry, Yonsei University, Wonju, South Korea (2008-2009)

Details of Employment (Past and Present):

Professor: School of Chemistry and Biochemistry, Thapar Institute of Engineering & Technology, Patiala-147004, India (2021-Continuing)

Associate Professor: School of Chemistry and Biochemistry, Thapar Institute of Engineering & Technology, Patiala-147004, India (2015-2021)

Assistant Professor: School of Chemistry and Biochemistry, Thapar Institute of Engineering & Technology, Patiala-147004, India (Jan., 2010-2015)

Research Scientist: Ranbaxy Research Laboratory (R&D), Gurgaon, India (May, 2009-Dec., 2009)

Research Scientist: Jubilant Chemsys Ltd. (CRO), Noida, India (May, 2006- Feb., 2008)

Part time Lecturer: Department of Chemistry, Guru Nanak Dev University, Amritsar, India (Aug, 2003-Dec, 2003 and Jan. 2004-Jan. 2005)

Junior Research Fellow: Department of Chemistry, Guru Nanak Dev University, Amritsar, India (2002-2006)

Teaching:

B.E./B.Tech.:  Applied Chemistry, Chemistry lab

M.Sc. (Chemistry): Organic Chemistry, Catalysis and Reagents, Reagents and Retrosynthesis, Stereochemistry and Photochemistry, Medicinal and Pharmaceutical Chemistry, Organic Reaction Mechanism, Organic Synthesis lab.

Honors/Awards:

Best Citation Award in SCBC: 2019 and 2020

Performance Incentive Award in TIET: 2019, 2018, 2017, 2015, 2014, 2013, 2012 and 2011

Joint CSIR-UGC (National Eligibility Test) in June, 2001 (Chemical Sciences)

Joint CSIR-UGC (National Eligibility Test) in December, 2001 (Chemical Sciences)

 

Membership:

Life Member of Chemical Research Society of India (CRSI) (LM 4081)

Foreign Collaboration:

Prof. In Howa Jeong, Department of Medicinal Chemistry, Yonsei University, South Korea; Dr. Manish Tripathi, Department of Pharmaceutical Sciences, UT Health Science Center, USA; Dr. Parvesh Singh, School of Chemistry and Physics, University of Kwa-Zulu Natal (UKZN), Westville campus, Durban, South Africa

Conference/workshop organization:

Organized “National Conference on Innovative Molecules for Sustainable Future NCIMSF-2013” held during 24-26 October, 2013.

Administrative Responsibilities: 

Deputy Coordinator, Centre for Excellence in Emerging Materials (CEEMS) (Aug. 16, 2022-Present)

Time table coordinator, School of Chemistry and Biochemistry (2017-Present)

PG Coordinator, School of Chemistry and Biochemistry (2022-Present)

PhD Coordinator, School of Chemistry and Biochemistry (2020-2022)

UG and PG Coordinator, School of Chemistry and Biochemistry (2016-2020)

Summer course coordinator, School of Chemistry and Biochemistry (2016-2019)

Editorial

Associate Editor in “Frontiers in Chemistry”, “Frontiers in Endocrinology” and “General Chemistry”

Research Papers Reviewed

Medicinal Research Review, Journal of Medicinal Chemistry, Journal of Organic Chemistry, Chemical Communication, Organic Chemistry Frontier, ACS Combinatorial Sciences, Sensor and Actuator: Chemical, European Journal of Medicinal Chemistry, ACS Omega, RSC Advances, New Journal of Chemistry, Med. Chem. Comm., Bioorganic and Medicinal Chemistry, Bioorganic and Medicinal Chemistry Letters, Bioorganic Chemistry, Journal of Molecular Liquid, Future Medicinal Chemistry, Research on Chemical Intermediate, Anticancer hybrids-A patent, Journal of Enzyme Inhibition and Medicinal Chemistry, ChemistrySelect, Letters in drug design and discovery, Phosphorous, sulfur, silicon and related elements, Monatshefte fur Chemie etc.

List of ongoing sponsored projects

  1. Ruthenium(II)-catalyzed dual C–H bond activation and oxidative annulation for regioselective synthesis of novel functionalized heterocycles, SERB, 2024-2027, 34 Lakhs
  2. Chemical synthesis, characterization and purification of N-acetyl-L-Tryptophan-N-glucoside, DRDO, 2024-2026, 23 Lakhs
  3. Multifunctional 1,8-naphthalimide derivatives for biological and medicinal applications, CEEMS, VT-TIET, 2021-2024, 15 Lakhs
  4. Development of a wearable, noninvasive, personalized home detection kit for early detection of breast cancer, CEEMS, VT-TIET, 2023-2026, 16.5 Lakhs

List of completed sponsored projects

1.   Transition metal catalyzed C-H functionalization of anticancer drug candidates, SERB, 2019-2022, 50 Lakhs

2.   Ruthenium Catalyzed C–H Bond Activation Strategy for C–C and C–X Bond Formation for Biological Active Compounds, CSIR, 2018-2021, 32 Lakhs

3.   Synthesis of fused heteroaromatic derivatives through molecular hybridization technique and  their in vitro evaluations as anticancer agents, DST, 2015-2019, 35 Lakhs

4.   Coupling of substituted quinazoline/xanthine and purine/ pyrimidine/benzimidazole: A novel scaffold for Kinase inhibitors, UGC, 2012-2015, 11.08 Lakhs

5. Heterocyclic substituted quinazoline and pyrazolo[3,4-d]pyrimidine derivatives: novel scaffold for Aurora Kinase inhibitors, CSIR, 2012-2015, 22.0 Lakhs

6.  Novel Scaffolds of P-glycoprotein modulators to overcome multidrug resistance in cancer cells, DST, 2011-2014, 22.0 Lakhs

7.   Hybrids of substituted benzimidazole and quinazoline analogous as anti-tuberculosis and anti-malarial activities, CSIR-OSDD, 2012, 5.5 Lakhs

 

Ph. D.  Thesis Supervision

  1. Name: Meenakshi Verma, Title of Thesis: Synthesis and in vitro evaluation of heterocyclic core moieties as anticancer agents, Completed.
  2. Name: Alka Sharma, Title of Thesis: Design, synthesis of benzimidazole core moieties and structure activity relationship studies based on in vitro evaluation as anticancer drug, Completed.
  3. Name: Prinka Singla, Title of Thesis: Synthesis and in vitro evaluation of fused heterocycles and triazine analogues, Completed.
  4. Name: Richa Goel, Title of Thesis: Synthesis and in vitro evaluation and structure activity relationship of some heterocyclic imidazoazine derivatives, Completed.
  5. Name: Richa Rani, Title of Thesis: Fluorescent dyads as sensors for certain cations and anions, Completed.
  6. Name: Iqubal Singh (SRF), Title of Thesis: Molecular hybridization approach for synthesis and evaluation of new heterocyclic compounds as potential anticancer agents, Completed.
  7. Name: Sudesh Rani (PF), Title of Thesis: Synthesis and in vitro evaluation of tri/tetraphenyl ethylene and naphthalimide derivatives for anticancer activity, Completed.
  8. Name: Dinesh Singla, Title of Thesis: C-H functionalization of heterocyclic moieties using transition metal catalyst for evaluation of anticancer activity, Completed.
  9. Name: Rekha Thakur, Title of Thesis: Transition Metal Catalyzed C-H Functionalization for the synthesis of bioactive heterocycles, Completed.
  10. Name: Saurabh Gupta, Title of Thesis: Synthesis and evaluation of naphthalimides and their hybrids with other heterocyclic moieties for anticancer activity, Completed.
  11. Name: Qurat Ul Ain, Title of Thesis: Synthesis, characterization and biological applications

of complexes of bisthiosemicarbazones with transition metals (Co, Ni, Cu, Zn), Completed.

  1. Name: Rohini Gupta, Title of Thesis: Synthesis, biological evaluation and molecular interactions of conjugates of heterocyclic moieties, Ongoing.
  2. Name: Anmol Jain (JRF), Title of Thesis: Synthesis and biological activity of polycyclic nitrogen/oxygen containing spiro and fused heterocyclic analogues, Ongoing.
  3. Name: Palak Sharma, Title of Thesis: Synthesis and Evaluation of quinoline, pyrazole and imidazopyrazine derivatives as anticancer agents, Ongoing.
  4. Name: Tanya, Title of Thesis: Synthesis and evaluation of five-membered heterocycles carrying pharmacophores as novel drug candidate for antibacterial activity, Ongoing.
  5. Name: Saanchi Sharma (JRF), Title of Thesis: Not finalized, Ongoing
  6. Name: Vikash Sharma, Title of Thesis: Not finalized, Ongoing
  7. Name: Jagroop Singh, Title of Thesis: Not finalized, Ongoing (SERB Project)
  8. Name: Priti, Title of Thesis: Not finalized, Ongoing (DRDO Project)
  9. Name: Sanket Mondal, Title of Thesis: Not finalized, Ongoing
  10. Name: Nandan Sarkar, Research Associate, 2019-2020 (CSIR Project)

M.Sc. Thesis Supervision

  1. Name: Rahul Rana, Title of Thesis: Design, Synthesis and In-vitro Antibacterial Activity of Naphthalimide-Triazine-Benzimidazole Hybrids, 2024
  2. Name: Abhinav Prashar, Title of Thesis: Ruthenium-catalyzed regioselective C-2 alkenylation of naphthalimide-benzothiazole conjugates, 2023
  3. Name: Vidhi Tyagi, Title of Thesis: Synthesis of N-acetyl-tryptophan glucoside, 2023
  4. Name: Komal Verma, Title of Thesis: Synthesis and interaction studies of Naphthalimide-Azide based probes with Serum Albumins, 2023
  5. Name: Pranshu, Title of Thesis: Ruthenium Catalyzed C5-H Alkenylation of Quinazolinone using Amide as Weak Directing Group, 2022
  6. Name: Jaspreet Kaur, Title of Thesis: Ru (II)-complexes as efficient catalyst for asymmetric reduction of ketones, 2021
  7. Name: Navreet Kaur Sehgal, Title of Thesis: Efficiency of Gold (I) complexes for the treatment of cancers, 2021
  8. Name: Konpal Raheja, Title of Thesis: Synthesis and characterization of N-butyl-(E/Z)-6-(3-(4-(1,2-diphenylprop-1-en-1-yl)phenoxy)prop-1-en-1-yl)-1H-benzo[de]isoquinoline-1,3(2H)-dione as anticancer agent, 2020
  9. Name: Navneet, Title of Thesis: Direct linking for the synthesis of bis-naphthalimide derivative, 2020
  10. Name: Kuldeep Singh, Title of Thesis: Synthesis and characterization of conjugate of benzimidazole and hydroxycoumarin as anticancer agents, 2020
  11. Name: Saurabh Gupta, Title of Thesis: Synthesis and characterization of 1,3,5-triazine and naphthalimide conjugates as anticancer agents, 2019
  12. Name: Rohini, Title of Thesis: Synthesis and characterization of indole and benzimidazole conjugates as anticancer agents, 2019
  13. Name: Diksha Bansal, Title of Thesis: Alkenylation of naphthalimide via ruthenium(II)-catalysed C-H activation, 2019
  14. Name: Jasleen Kaur, Title of Thesis: Synthesis and characterization of pyrazole and perimidine conjugates as anticancer agents, 2018
  15. Name: Akanksha, Title of Thesis: Synthesis of molecular hybridization based aromatic linked naphthalimide-benzimidazole conjugates, 2018
  16. Name: Bhavya Khurana, Title of Thesis: Synthesis of indole-benzothiazole-acridone hybrids for anticancer activity, 2017
  17. Name: Mandeep Kaur, Title of Thesis: Synthesis of tamoxifen derivatives as anticancer agents, 2017
  18. Name: Nitya Chawla, Title of Thesis: Synthesis of naphthalimide and imidazo[1,2-a]pyridine derivatives as anticancer agents, 2017
  19. Name: Jasdeep Kaur, Title of Thesis: Synthesis of N-acetamide substituted naphthalimide derivatives, 2016
  20. Name: Sheenam Kaushal, Title of Thesis: Synthesis of N-acetamide substituted naphthalimide derivatives, 2016
  21. Name: Yashika Taparia, Title of Thesis: Ring and Side Chain Alkylation of Toluene with Methanol over Modified Zeolite Beta, 2016
  22. Name: Sheryl Sharma, Title of Thesis: Synthesis of N-acetamide substituted naphthalimide derivatives, 2015
  23. Name: Charanpreet Kaur, Title of Thesis: Synthesis and photophysical studies of thiazolidin-2,4-dione derivatives, 2014
  24. Name: Sarita, Title of Thesis: Synthesis and DNA interaction studies of 2-(acenaphtho[1,2-b]quinoxalin-3-ylthio)aniline, 2014
  25. Name: Arpan deep Kaur, Title of Thesis: Synthesis and characterization of maleimide derivatives, 2013
  26. Name: Shweta Bindal, Title of Thesis: Synthesis and In vitro evaluation of Coumarin - benzimidazole hybrids as anticancer agents, 2012
  27. Name: Rohini, Title of Thesis: Regioselective nitration/amination of alkylated benzimidazole, 2011
  28. Name: Renukamal, Title of Thesis: Rhodamine based chemosensor for selective to differential sensing of copper and iron, 2011

Peer-Reviewed Publications

  1. Rohini Gupta, Kamaldeep Paul, A fluorescent “Turn-ON” probe with rapid and differential response to HSA and BSA: Quantitative detection of HSA in urine, J. Mat. Chem. B, 2024, 12, 9037-9049
  2. Rekha Thakur, Kamaldeep Paul, Ruthenium(II)-catalyzed sequential C-H/N-H alkene annulation cascade of phenanthroimidazoles: Synthesis and photophysical studies, J. Org. Chem., 2024, 89, 9, 6016–6026.
  3. Saurabh Gupta, Vijay Luxami, Kamaldeep Paul, Bacterial cell death to overcome drug resistance with multitargeting bis-naphthalimides as potent antibacterial agents against Enterococcus faecalis. J. Mat. Chem. B, 2024, 12 (23), 5645 – 5660
  4. Rohini Gupta, Kamaldeep Paul, Investigating the Serum Albumin Binding Behavior of Naphthalimide Based Fluorophore Conjugates: Spectroscopic and Molecular Docking Approach, ChemMedChem, 2024, 19 (15), e202400114.
  5. Astha Palta, Gulshan Kumar, Sunidhi Sharma, Diptiman Choudhury, Kamaldeep Paul, Vijay Luxami, Highly specific benzothiazole based Schiff base for ratiometric detection of hypochlorite ion (ClO-) in aqueous system: Real application in biological imaging, New J. Chem., 2024, 48, 15402-15413.
  6. Astha Palta, Gulshan Kumar, Kamaldeep Paul, Vijay Luxami, Highly selective colorimetric and fluorescent probe for F− and P2O74− based on AIEE and dual ESIPT, J. Mol. Struct. 2024, 1316, 138880.
  7. Dinesh Singla, Vijay Luxami, Kamaldeep Paul, Pd(II)-catalyzed benzimidazole-assisted annulation of 3-(1H-benzo[d]imidazol-2-yl)-2H-chromen-2-one: Access to imidazo[1,2-a]chromeno[3,4-c]pyridine, Eur. J. Org. Chem., 2023, 26(34), e202300531.
  8. Saurabh Gupta, Kamaldeep Paul, Membrane-active substituted triazines as antibacterial agents against Staphylococcus aureus with potential for low drug resistance and broad activity, Eur. J. Med. Chem., 2023, 258, 115551.
  9. Dinesh Singla, Vijay Luxami, Kamaldeep Paul, Eosin Y mediated photo-catalytic C-H functionalization: C-C and C-S bond formation, Org. Chem. Front., 2023, 10(1), 237–266.
  10. Saurabh Gupta, Kamaldeep Paul, DNA damage and intercalation by elinafide modified bis-naphthalimides for their anticancer activity, J. Mol. Liq., 2023, 382, 121980.
  11. Qurat Ul Ain, Iqubal Singh, Raanan Carmieli, Ahmet Savci, Kamaldeep Paul, Rekha Sharma, Substituted 2,5 thiophene dicarboxaldehyde bisthiosemicarbazones and their copper(II) complexes: Synthesis, structure elucidation, HSA binding, biological activities and docking studies, J. Mol. Str., 2023, 1291, 135996.
  12. Parnashabari Sarkar, Saurabh Gupta, Udaya Kumar, Dipankar Das, Saurav Sutradhar, Kamaldeep Paul, N. K. Lokanath, Biswa Nath Ghosh, Protein interactions and drug displacement studies of novel copper(II) and zinc(II) complexes of a dipyrazinylpyridine ligand, J. Mol. Liq., 2023, 387, 122561.
  13. Iqubal Singh, Gulshan Kumar, Astha Palta, Vijay luxami, Kamaldeep Paul, Naphthalimide-benzimidazole conjugate towards “Turn-on” recoginition of Hg2+ in pure aqueous medium, Inorg. Chim. Acta, 2023, 557, 121684.
  14. Nitin Tandon, Rekha Thakur, Runjhun Tandon, Iqubal Singh, Kamaldeep Paul, Aeyaz Ahmad Bhat, C−H Functionalized molecules: Synthesis, reaction mechanism, and biological activity, Asian J. Org. Chem., 2023, 12(7), e202300017.
  15. Md. Shahidul Islam, Parvesh Singh, Kamaldeep Paul, Antidiabetic molecular targets: Updates on old and emerging targets and their small molecule modulators, Front. Chem., 2023, 11, 1150026 (Editorial)
  16. Astha Palta, Dinesh Singla, Vijay Luxami, Kamaldeep Paul, Coumarin-pyrazole based fluorescent sensor for selective detection of dopamine in aqueous medium, ChemistrySelect, 2023, 8(31), e202301864.
  17. Dinesh Singla, Kamaldeep Paul, One-Pot cascade access to Ru(II)-catalyzed regioselective C(sp2)-H activation/alkenylation of chromeno[4,3-c]pyrazol-4-ones and their emission solvatochromic studies, J. Org. Chem., 2022, 87(24), 16436–16448
  18. Dinesh Singla, Kamaldeep Paul, Ru(II)-catalyzed regioselective C(5)–H functionalization of quinazolinone-coumarin conjugates: Synthesis and photophysical studies, J. Org. Chem., 2022, 87(16), 10673-10683
  19. Rekha Thakur, Iqubal Singh, Kamaldeep Paul, Ruthenium(II)-catalyzed C-H alkenylation of 1,8-naphthalimide with cyclic imide as a weakly coordinating directing group, Asian J. Org. Chem., 2022, 11(3), e202100798
  20.  Sudesh Rani, Sourabh Gupta, Vijay Luxami, Kamaldeep Paul, A novel target and biomarker benzothiazolyl-naphthalimide probes for precise and selective detection of serum albumin and anticancer activity, New J. Chem., 2022, 46(25), 12082–12092
  21. Rinku Malhi, Jerry P. Jasinski, Manpreet Kaur, Kamaldeep Paul, Rekha Sharma, Synthesis, characterization and antitubercular activities of heterocyclic selenosemicarbazones, Bioorg. Chem. 2022, 126, 105907
  22. Nitin Tandon, Vijay Luxami, Runjhun Tandon, Kamaldeep Paul, Recent developments on 1,8-naphthalimide moiety as potential target for anticancer agents. Bioorg. Chem. 2022, 121, 105677.
  23. Iqubal Singh, Vijay Luxami, Diptiman Chaudhary, Kamaldeep Paul, Synthesis and photobiological applications of naphthalimide-benzothiazole conjugates: Cytotoxicity and topoisomerase IIa inhibitors, RSC Adv. 2022, 12(1), 483.
  24. Nitin Tandon, Vijay Luxami, Runjhun Tandon and Kamaldeep Paul, Interleukin receptor antagonists and janus kinase inhibitors repurposed for treatment of COVID-19, Mini Rev. Med. Chem. 2022, 22(21), 2752–2768.
  25.  Meenakshi Patyal, K. Kaur, Nidhi Gupta, Ashok Kumar Malik, Kamaldeep Paul, A comparative study of macrocyclic Mn(II) nanocomplex synthesized using sonication-assisted and conventional methods for biomedical applications, Asian J. Chem., 2022, 34(9), 2424–2430
  26. Meenakshi Patyal, K. Kaur, P. Sharma, Ashok Kumar Malik, Kamaldeep Paul, Nanoscale synthesis, structural elucidation, DFT, and biological activity of amide appended transition metal(II) macrocyclic complexes in drug delivery system, J. Coord. Chem., 2022, 75(19-24), 2843–2857
  27. Sudesh Rani, Konpal Raheja, Vijay Luxami, Kamaldeep Paul, A review on diverse heterocyclic compounds as the privileged scaffolds in non-steroidal aromatase inhibitors, Bioorg. Chem. 2021, 113, 105017.
  28. Nitin Tandon, Vijay Luxami, Divya Kant, Runjhun Tandon, Kamaldeep Paul, Current progress, challenges and future prospects of indazoles as protein kinase inhibitors for the treatment of cancer, RSC Adv. 2021, 11(41), 25228-25257.
  29. Sudesh Rani, Vijay Luxami, Kamaldeep Paul, Synthesis of triphenylethylene-naphthalimide conjugates as topoisomerase-IIα inhibitor and HSA binder, ChemMedChem, 2021, 16(11), 1821-1831.
  30. Rohini Gupta, Vijay Luxami, Kamaldeep Paul, Insights of 8-hydroxyquinolines: A novel target in medicinal chemistry, Bioorg. Chem., 2021, 108, 104633.
  31. Gulshan Kumar, Iqubal Singh, Richa Goel, Vijay Luxami, Kamaldeep Paul, Dual-channel ratiometric recognition of Al3+ and F− ions through an ESIPT-ESICT signalling mechanism, Spectrochimica Acta - Part A, 2021, 247, 119112.
  32. Nitin Tandon, Vijay Luxami, Runjhun Tandon and Kamaldeep Paul, Recent approaches of repositioning and traditional drugs for the treatment of COVID-19 pandemic outbreak, Mini Rev. Med. Chem., 2021, 21 (8), 952-968
  33. Ruhi Mehta, Kamaldeep Paul, Vijay Luxami, 1-Oxo-1H-phenalene-2,3-dicarbonitrile based sensor for selective detection of cyanide ions in industrial waste, J. Mol. Str., 2021, 1234, 130077.
  34. Geetika Rani, Vijay Luxami, Kamaldeep Paul, Traceless directing group: A novel strategy in regiodivergent C-H functionalization, Chem. Commun., 2020, 56(83), 12479-12521 (Top 5% citation in 2021).
  35.       Ashiq Khan, Kamaldeep Paul, Iqubal Singh, Rekha Sharma, Copper(I) and silver(I) complexes of anthraldehyde thiosemicarbazone: Synthesis, structure elucidation: In vitro anti-tuberculosis/cytotoxic activity and interactions with DNA/HSA, Dalton Trans., 2020, 49(47), 17350–17367
  36. Sudesh Rani, Kamaldeep Paul, Triphenylethylene analogues: Design, synthesis and evaluation of antitumor activity and topoisomerase inhibitors, Eur. J. Med. Chem., 2020, 208, 112775.
  37. Runjhun Tandon, Vijay Luxami, Nitin Tandon, Kamaldeep Paul, Recent advances in the synthesis of tamoxifen and analogues in organic synthesis, Asian J. Org. Chem., 2020, 9(10), 1432-1465.
  38.   .. Tarlok S.Lobana, Mani Kaushal, Ritu Bala, Lovedeep Nim, Kamaldeep Paul, Daljit S. Arorab, Astha Bhatia, Saroj Arora, Jerry P. Jasinskie, Di-2-pyridylketone-N-1-substituted thiosemicarbazone derivatives of copper(II): Biosafe antimicrobial potential and high anticancer activity against immortalized L6 rat skeletal muscle cells, J. Inorg. Biochem., 2020, 212, 111205.
  39. Gulshan Kumar, Kamaldeep Paul, Vijay Luxami, Deciphering the excited state intramolecular charge-coupled double proton transfer in an asymmetric quinoline–benzimidazole system, New J. Chem., 2020, 44, 12866-12874
  40. Iqubal Singh, Vijay Luxami, Kamaldeep Paul, Synthesis, cytotoxicity, pharmacokinetic profle, binding with DNA and BSA of new imidazo[1,2-a]pyrazine-benzo[d]imidazol-5-yl hybrids, Sci. Reports, 2020, 10(1), 6534
  41. Iqubal Singh, Vijay Luxami, Kamaldeep Paul, Synthesis of naphthalimide-phenanthro[9,10-d]imidazole derivatives: In vitro evaluation, binding interaction with DNA and topoisomerase inhibition, Bioorg. Chem. 2020, 96, 103631
  42. Iqubal Singh, Vijay Luxami, Kamaldeep Paul, Spectroscopy and molecular docking approach for investigation on the binding of nocodazole to human serum albumin, Spectrochimica Acta Part A, 2020, 235, 118289
  43. Dharmender Sharma, Jerry P. Jasinski, Victoria A. Smolinski, Manpreet Kaur, Kamaldeep Paul, Rekha Sharma, Synthesis and structure of complexes (NiII, AgI) of substituted benzaldehyde thiosemicarbazones and antitubercular activity of NiII complex, Inorg. Chimi. Acta, 2020, 499, 119187
  44. Nitin Tandon, Vijay Luxami, Runjhun Tandon, Kamaldeep Paul, Recent approaches of repositioning and traditional drugs for the treatment of cOVID-19 pandemic outbreak, Mini Rev. Med. Chem. 2020, 21(8), 952-968
  45. Iqubal Singh, Vijay Luxami, Kamaldeep Paul, Effective synthesis of benzimidazoles-imidazo[1,2-a]pyrazine conjugates: A comparative study of mono-and bis-benzimidazoles for antitumor activity, Eur. J. Med. Chem. 2019, 180, 546-561.
  46. Iqubal Singh, Vijay Luxami, Kamaldeep Paul, Discovery, synthesis and evaluation of naphthalimide-benzimidazole conjugates as DNA inhibitors and potential antitumor agents, Org. Biomol. Chem., 2019, 17, 5349-5366.
  47. Iqubal Singh, Richa Rani, Vijay Luxami, Kamaldeep Paul, Synthesis of 5-(4-(1H-phenanthro[9,10-d]imidazol-2-yl)benzylidene)thiazolidine-2,4-dione as promising DNA and serum albumin-binding agents and evaluation of antitumor activity, Eur. J. Med. Chem. 2019, 166, 267-280.
  48. Runjhun Tandon, Iqubal Singh, Vijay Luxami, Nitin Tandon, Kamaldeep Paul Recent advances and developments of in vitro evaluation of heterocyclic moieties on cancer cell lines, Chem. Rec. 2019, 19, 362–393.
  49. Gulshan Kumar, Richa Rani, Kamaldeep Paul, Vijay Luxami, Single molecular platform displaying PET and hydrolysis sensing mechanism for differential detection of metal ions, J. Photochem. Photobiol. A: Chemistry, 2019, 380, 111845.
  50. Ruhi Mehta, Pawandeep Kaur, Diptiman Choudhary, Kamaldeep Paul, Vijay Luxami, Al3+ induced hydrolysis of Rhodamine-based schiff-base: Applications in cell imaging and ensemble as CN- sensor in 100 % aqueous medium, J. Photochem. Photobiol. A: Chemistry, 2019, 380, 111851.
  51. … Mohmmad Yusuf, Shehneela Nisa Kamaldeep Paul, New biphenyl based bispyrazolines: Synthesis, antimicrobial and docking studies, J. Het. Chem., 2019, 56 (9), 2659-2670.
  52. Simranjit Singh, Narinder Arora, Kamaldeep Paul, Rajiv Kumar, Rajesh Kumar, FTIR and rheological studies of PMMA-based nano-dispersed gel polymer electrolytes incorporated with LiBF4 and SiO2, Ionics, 2019, 25, 1495–1503.
  53. Ashiq Khan, Jerry P. Jasinski, Victoria A. Smolenski, Ethan P. Hotchkiss, Patrick T. Kelley, Zachary A. Shalit, Manpreet Kaur, Kamaldeep Paul, Rekha Sharma, Enhancement in anti-tubercular activity of indole based thiosemicarbazones on complexation with copper(I) and silver(I) halides: Structure elucidation, evaluation and molecular modeling, Bioorg. Chem., 2018, 80, 303-318.
  54. Gulshan Kumar, Richa Rani, Kamaldeep Paul, Vijay Luxami, Donor-p-Acceptor (D-p-A) Dyad for ratiometric detection of Hg2+ and PPi, New J. Chem., 2018, 42, 12729-12736.
  55. Gulshan Kumar, Nidhi Gupta, Kamaldeep Paul, Vijay Luxami, Acrylonitrile embedded benzimidazole-anthraquinone based chromofluorescent sensor for ratiometric detection of CN− ions in bovine serum albumin, Sens. Actuators B Chem., 2018, 267, 549-558.
  56. Gulshan Kumar, Kamaldeep Paul, Vijay Luxami, Aggregation induced emission-excited state intramolecular proton transfer based “off-on” fluorescent sensor for Al3+ ions in liquid and solid state, Sens. Actuators B Chem., 2018, 263, 585-593.
  57. Akul Sen Gupta, Gulshan Kumar, Kamaldeep Paul, Vijay Luxami, BINOL-based differential chromo-fluorescent sensor and its application in miniaturized 1-2/4-2 bit encoders and decoders, New J. Chem., 2018, 42, 2491-2497.
  58. …P Puri, G Kumar, K Paul, V Luxami, Self-agglomerated crystalline needles harnessing ESIPT and AIEE features for the ‘turn-on’fluorescence detection of Al3+ ions, New J. Chem. 2018, 42 (23), 18550-18558.
  59. Gulshan Kumar, Richa Goel, Kamaldeep Paul, Vijay Luxami, Investigation of rotameric conformations of substituted imidazo[1,2-a]pyrazine: Experimental and theoretical approaches,  RSC Adv., 2018, 8, 9707-9717.
  60. Runjhun Tandon, Vijay Luxami, Harmanjit Singh Dosanjh, Nitin Tandon, Kamaldeep Paul, Insulin therapy for diabetes epidemic: A patent review, Curr. Drug Deliv., 2018, 15(6), 777-794.
  61. Akul Sen Gupta, Kamaldeep Paul, Vijay Luxami, A new ': Turn-on ' PET-CHEF based fluorescent sensor for Al3+ and CN- ions: Applications in real samples, Anal. Methods, 2018, 10, 983-990.
  62. Richa Goel, Vijay Luxami, Kamaldeep Paul, Synthesis of new triazole based imidazo[1,2-a]pyrazine-benzimidazole conjugates: H-bonding assisted FRET efficient ratiometric detection of pyrophosphate, J. Photochem. Photobiol. A: Chemistry, 2017, 348, 102–109.
  63. Runjhun Tandon, Vijay Luxami, Harsovin Kaur, Nitin Tandon, and Kamaldeep Paul, 1,8-Naphthalimide: A potent DNA intercalator and target for cancer therapy, Chem. Rec. 2017, 17, 956-993.
  64. Akul Sen Gupta, Kamaldeep Paul, Vijay Luxami, A fluorescent probe with “AIE + ESIPT” characteristics for Cu2+ and F− ions estimation, Sens. Actuators B Chem., 2017, 246, 653-661.
  65. Richa Goel, Sheryl Sharma, Kamaldeep Paul, Vijay Luxami, Naphthalimide based chromofluorescent sensor and DNA intercalator: Triggered by Hg2+/HSO4− cleavage reaction, Sens. Actuators B Chem., 2017, 246, 776-782.
  66. Prinka Singla, Vijay Luxami, Kamaldeep Paul⁎ Quinazolinone-benzimidazole conjugates: Synthesis, characterization, dihydrofolate reductase inhibition, DNA and protein binding properties, J. Photochem. Photobiol. A: Biology, 2017, 168, 156-164.
  67. Akul SenGupta, Kamaldeep Paul, Vijay Luxami, ESIPT coupled RAHBprobe for estimation of cyanide in human blood serum/plasma like solution using chemodosimetric approach, ChemistrySelect, 2017, 2, 800-804.
  68. Prinka Singla, Vijay Luxami, Raja Singh, Vibha Tandon, Kamaldeep Paul, Novel pyrazolo[3,4-d]pyrimidine with 4-(1H-benzimidazol-2-yl)-phenylamine as broad spectrum anticancer agents: Synthesis, cell based assay, topoisomerase inhibitors, DNA intercalation and bovine serum albumin studies, Eur. J. Med. Chem. 2017, 126, 24-35.
  69. Prinka Singla, Vijay Luxami, Kamaldeep Paul, Synthesis and in vitro evaluation of novel triazine analogues as anticancer agents and their interaction studies with bovine serum albumin, Eur. J. Med. Chem. 2016, 117, 59-69.
  70. Richa Goel, Vijay Luxami, Kamaldeep Paul, Imidazo[1,2-a]pyridines: promising drug candidate for antitumor therapy, Curr. Topics Med. Chem., 2016, 16(30), 3590-3616.
  71. Prinka Singla, Vijay Luxami, Kamaldeep Paul, Triazine–benzimidazole conjugates: synthesis, spectroscopic and molecular modelling studies for interaction with calf thymus DNA, RSC Adv., 2016, 6, 14741.
  72. Richa Goel, Vijay Luxami, Kamaldeep Paul, Synthesis of energy transfer cassettes via click and Suzuki–Miyaura cross coupling reactions, RSC Adv., 2016, 6, 37664.
  73. Prinka Singla, Vijay Luxami, Kamaldeep Paul, Pyrrolo[2,3-b]pyridine derivatives: Synthesis and preliminary evaluation of their calf thymus DNA binding properties, ChemistrySelect, 2016, 1, 4772-4777.
  74. Richa Rani, Kamaldeep Paul, Vijay Luxami, An NBD-based two-in-one Cu2+/Ni2+
    chemosensor with differential charge transfer processes, New J. Chem., 2016, 40, 2418.
  75. Richa Rani, Gulshan Kumar, Kamaldeep Paul, Vijay Luxami, Thiazolidine based differential chromo-fluorescent sensor for Cu2+ and CN- ions: Elaboration as logic devices. J. Lumin., 2016, 180, 292–300.
  76. Akul Sen Gupta, Aparna Garg, Kamaldeep Paul, Vijay Luxami, Differential sensing of fluoride and cyanide ions by using dicyano substituted benzimidazole probe, J. Lumin., 2016, 173, 165–170.
  77. Prinka Singla, Vijay Luxami and Kamaldeep Paul, Synthesis, in vitro antitumor activity, dihydrofolate reductase inhibition, DNA intercalation and structure–activity relationship studies of 1,3,5-triazine analogues, Bioorg. Med. Chem. Lett., 2016, 26, 518–523.
  78. Akul Sen Gupta, Kamaldeep Paul, Vijay Luxami, Benzimidazole based ratiometric chemosensor for detection of CN and Cu2+ ions in protic/aqueous system: Elaboration as XOR logic operation, Inorg. Chim. Acta, 2016, 443, 57–63.
  79. Ashiq Khan, Jerry P. Jasinski, Victoria A. Smoleaski, Kamaldeep Paul, Gurpinder Singh, Rekha Sharma, Synthesis, structure and cytotoxic evaluation of complexes of N1 substituted-isatin-3-thiosemicarbazone with copper (I) halides. Inorg. Chim. Acta, 2016, 449, 119–126.
  80. Alka Sharma, Vijay Luxami, Sanjai Saxena and Kamaldeep Paul, Benzimidazole-Quinazolines: In vitro Evaluation, Quantitative Structure Activity Relationship and Molecular Modeling as Aurora Kinase Inhibitors, Arch. Pharm. Chem. Life Sci. 2016, 349, 193–201.
  81. Alka Sharma, Vijay Luxami, Kamaldeep Paul, Csp2–O and C–C bond formation via Pd-catalyzed coupling reaction of 2,4-dichloroquinazoline, J. Het. Chem., 2016, 53, 241.
  82. Alka Sharma, Vijay Luxami and Kamaldeep Paul, Purine-benzimidazole hybrids: Synthesis, single crystal determination and in vitro evaluation of antitumor activities, Eur. J. Med. Chem. 2015, 93, 414-422.
  83. Prinka Singla, Vijay Luxami, Kamaldeep Paul, Triazine as a promising scaffold for its versatile biological behavior, Eur. J. Med. Chem. 2015, 102, 39-57.
  84. Richa Goel, Vijay Luxami, Kamaldeep Paul, Recent advances in development of imidazo[1,2-a]pyrazines: synthesis, reactivity and their biological applications, Org. Biomol. Chem., 2015, 13, 3525-3555 (Inside Cover Picture).
  85. Richa Goel, Vijay Luxami and Kamaldeep Paul, Synthetic approaches and functionalizations of imidazo[1,2-a]pyrimidines: an overview of the decade, RSC Adv., 2015, 5, 81608.
  86. Meenakshi Verma, Vijay Luxami and Kamaldeep Paul, Synthesis, in vitro evaluation and DNA interaction studies of N-allyl naphthalimide analogues as anticancer agents, RSC Adv., 2015, 5, 41803.
  87. Richa Goel, Vijay Luxami, Kamaldeep Paul, Synthesis, in vitro anticancer activity and SAR studies of arylated imidazo[1,2-a]pyrazine-coumarin hybrids, RSC Adv., 2015, 5, 37887-37895.
  88. Vijay Luxami, Richa Rani, Alka Sharma, Kamaldeep paul, Quinazoline-benzimidazole hybrid as optical sensor for cyanide and Pb2+ ions and Aurora kinase inhibitor, J. Photochem. Photobiol. A: Chemistry, 2015, 311, 68–75.
  89. Prinka Singla, Vijay Luxami, Kamaldeep Paul*, Triazine–benzimidazole hybrids: Anticancer activity, DNA interaction and dihydrofolate reductase inhibitors, Bioorg. Med. Chem., 2015, 23, 1691–1700.
  90. Akul Sen Gupta  Kamaldeep Paul, Vijay Luxami, Ratiometric fluorescent chemosensor for fluoride  ion based on inhibition of excited state intramolecular proton transfer, Spectrochimica Acta Part A: Mol. Biomol. Spec., 2015, 67, 67-72.
  91. Meenakshi Verma, Vijay Luxami and Kamaldeep Paul, Synthesis of new 2,3-disubstituted pyridines containing 1,2,3-triazole in the side-chain via one-pot copper-catalyzed azide-alkyne cycloaddition, ARKIVOC 2015 (vii) 28-41.
  92. Vijay Luxami,  Akul Sen Gupta,  Kamaldeep Paul, Dansyl-antipyrine dyad as fluorescent sensor for Cu2+ and F-: Sequential XNOR logic operation, New J. Chem., 2014, 38, 2841.
  93. Richa Goel, Vijay Luxami, Kamaldeep Paul, Palladium catalyzed novel monoarylation and symmetrical/unsymmetrical diarylation of imidazo[1,2-a]pyrazines and their in vitro anticancer activities, RSC Adv., 2014, 4, 9885-9892.
  94. Prinka Singla, Vijay Luxami, Kamaldeep Paul, Benzimidazole-biologically attractive scaffold for protein kinase inhibitors, RSC Adv., 2014, 4, 12422-12440.
  95.  Kamaldeep Paul, Alka Sharma, Vijay Luxami, Synthesis, in vitro antitumor evaluation and molecular modeling of primary amine substituted quinazoline linked benzimidazole, Bioorg. Med. Chem. Lett., 2014, 24(2), 624-629.
  96. Meenakshi Verma, Vijay Luxami, Kamaldeep Paul, Synthesis, in vitro evaluation and molecular modeling of naphthalimide analogues as anticancer agents, Eur. J. Med. Chem., 2013, 68, 352-360.
  97. Alka Sharma, Vijay Luxami, Kamaldeep Paul, Synthesis, single crystal and antitumor activities of benzimidazole- quinazoline hybrids, Bioorg. Med. Chem. Lett., 2013, 3(11), 3288-3294.
  98. Kamaldeep Paul, Shweta Bindal, Vijay Luxami, Synthesis of new conjugated coumarin-benzimidazole hybrids and their anticancer activity, Bioorg. Med. Chem. Lett., 2013, 23(12), 3667-3672.
  99. Vijay Luxami, Kamaldeep Paul, In Howa Jeong, Pyrophosphate selective fluorescent probe and molecular flip flop, Dalton Trans., 2013, 42, 3783-3786.
  100.  Vijay Luxami, Renukamal, Kamaldeep Paul, Subodh Kumar, A dual-responsive chromo-fluorescent probe for detection of Zn2+ and Fe3+ via two different spproaches, RSC Adv., 2013, 3, 9189-9192.
  101. Vijay Luxami, Meenakshi Verma, Richa Rani, Kamaldeep Paul, Subodh Kumar, FRET

       ….based ratiometric detection of Hg2+ and biothiols using naphthalimide-rhodamine dyads, Org. Biomol.  Chem., 2012, 10, 8076-8081.

  1. Ji Hoon Choi, Kamaldeep Paul, Yeon Hui jung, In Howa Jeon. Cross-coupling reaction of β-β-difluoro-a-phenylvinylstannane with alkenyl iodides: novel approach to 2-phenyl-1,1-difluoro-1,3-butadiene, Bull. Korean Chem. Soc., 2010, 31(1), 25-26.
  2. Kamaldeep Paul, Ji Hye Hwang, Ji Hoon Choi, In Howa Jeong. Synthesis of 2-floro-3-phenylthio-1,3-butadiene and 2-trifluoromethyl-3-phenythio-1,3-butadiene and their reactivity, Org. Lett., 2009, 11(20), 4728.
  3. Palwinder Singh, Jatinder Kaur, Kamaldeep Paul, Reactions of 5-benzoyl-/5-carbaldehyde-/5-(3-phenyl-acryloyl)-6-hydroxy-1H-pyrimidin-2,4-diones with amines: anti-cancer and metal sequestering properties, Ind. J. Chem., Sect. B, 2008, 47B (2), 291-296.
  4. Palwinder Singh, Kamaldeep Paul, Wolfgang Holzer, Synthesis of pyrazole-based hybrid molecules: Search for potent multidrug resistance modulators, Bioorg. Med. Chem., 2006, 14, 5061.
  5.  Palwinder Singh, Kamaldeep Paul, Studies of interaction between uracil-based hybrid molecules and P-glycoprotein-Search for multidrug resistance modulators, Bioorg. Med. Chem., 2006, 14, 7183.
  6. Palwinder Singh, Kamaldeep Paul, Anti-cancer activities of 5-acyl-6-[2-hydroxy/benzyloxy-3-(amino)-propylamino]-1,3-dialkyl-1H-pyrimidin-2,4-diones, Bioorg. Med. Chem., 2006, 14, 8622.
  7. Palwinder Singh, Kamaldeep Paul, A practical approach for spiro- and 5-monoalkylated barbituric acids, J. Het. Chem., 2006, 43, 603-612.
  8. Palwinder Singh, Kamaldeep Paul, A simple synthesis of 5-spirobarbituric acids and transformations of spirocyclo propane barbiturates to 5-substituted barbiturates, Ind. J. Chem., Sect. B, 2006, 45B, 247.
  9. Palwinder Singh, Kamaldeep Paul, Wolfgang Holzer. Synthesis of 5-acyl-6-[2-hydroxy-3-(amino)-propylamino]-1,3-dialkyl-1H-pyrimidine-2,4-diones, Org. Biomol. Chem. 2005, 3 (21), 3958.
  10. Palwinder Singh, Kamaldeep Paul, A facile synthesis of 5-acylbarbituric acids under microwave irradiations Ind. J. Chem., Sect. B, 2005, 44B, 1105-1108.
  11. Palwinder Singh, Kamaldeep Paul, Multidrug Resistance: An obstacle to the successful chemotherapy of cancer- its mechanism and remedies via MDR modulators, Nat. Acad. Sci. Lett., 2005, 28 (11-12), 365-372.

Invited talk/outreach activity 

  1. Invited Lecture at 4th National Conference on “Chemistry for the Sustainable Future”. This National Conference at Punjabi University, Patiala, 22-23 February 2024. 
  2. Keynote Speaker at “International Conference on Synthetic and Pharmaceutical Chemistry (ICSPC 2023)” at Lovely Professional University, Phagwara, Punjab, 15-16 September 2023
  3. Invited Lecture at Refresher Course in Chemistry, Punjabi University, Patiala, 02 December 2021
  4. Invited Lecture on “Impact of Stereochemistry in Drug Designing and Development: Beyond the shape of the pill", DAV College, Hoshiarpur, 28 October 2021
  5. Invited Lecture at KMV College, Jalandhar, October 2021
  6. Invited Lecture at Chandigarh University, Chandigarh, February 2020
  7. Invited Lecture at Chandigarh Group of Colleges, Landran, December 2019
  8. Invited Lecture at Chandigarh Group of Colleges, Landran, March 2019
  9. Invited Lecture on “Stereochemistry and its Role in Drug Design” at Refresher Course in Chemistry, Punjabi University, Patiala, 15 October 2017
  10. Latest Development in the Emerging Green Technology Based on the Application of Microwave Energy to Material Processing, PTU, Jalandhar, Aug. 20-22, 2012.
  11. National Conference on recent advances in chemical & environmental sciences, Modi College, Patiala, March 3, 2012.
  12. 4th NIPER (RBL)-CDRI symposium on Medicinal and Pharmaceutical Chemistry, CDRI, Lucknow, Feb, 23-25, 2012.
  13. The 101 st National Meeting of the Korean Chemical Society, Kintex, South Korea, April, 21-23, 2008.
  14. A National Symposium on New Challenges of Chemistry, Guru Nanak Dev University, Amritsar, March 20-21, 2006.
  15. A National School on New Dimension to NMR: From Molecules to Human Behavior, NEHU, Shilong, Meghalaya, May 23-June 3, 2005.
  16. IUPAC International Conference on Biodiversity and Natural Products: Chemistry and Medical Applications, New Delhi, January 26-31, 2004.
  17. National Workshop on Curriculum Development in Natural Products at Postgraduate Level, NIPER, S.A.S. Nagar, Punjab, November 25-27, 2003.
  18. National Bioorganic Symposium – 7, Guru Nanak Dev University, Amritsar, November 9-10, 2001.
  19. National Conference on Recent Advances in Thermodynamics of Chemical and Biological Systems, Guru Nanak Dev University, Amritsar, May 7-9, 2001

Presentation in International Conferences 

  1. Keynote Speaker at “International Conference on Organic and Inorganic Chemistry” in Paris, France, 18-20 February 2019
  2. 15th tetrahedron conference-Asian Edition: Challenges in Bioorganic and Medicinal Chemistry, Singapore EXPO, Singapore, 28-31 October 2014
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