Group webpage: Tyagi Research Group

Area of Research:

Development of green and sustainable organic reactions using enzymes or electricity.

Synthesis of organic molecules using isocyanides or diazo compounds as a versatile starting material.

Professional Affiliations/Education:

Associate Professor (September 2024-Present)

Department of Chemistry and Biochemistry, Thapar Institute of Engineering & Technology (Deemed to be a university), Patiala, India

Assistant Professor (December 2017 – August 2024)

Department of Chemistry and Biochemistry, Thapar Institute of Engineering & Technology (Deemed to be a university), Patiala, India

Post-Doctoral fellow (September 2016-September 2017)

Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, USA. Post-Doctoral fellow (December 2013-August 2016) (with Prof Rudi Fasan) Department of Chemistry, University of Rochester, NY, USA.

Education:

Ph.D. (January 2009-November 2013)

CSIR-CDRI, Lucknow/JNU, New Delhi, India

Teaching Activities:

PCY 403: Heterocyclic chemistry and natural products PCY 304: Interpretative spectroscopy

PCY 217: Advanced organic chemistry lab PBC 442: Biocatalysis

UCB 009: Chemistry for undergraduate UCY401: Organic Chemistry

DCB001: Advanced Instrumentation techniques

Research Supervision:  Ph.D. thesis Completed: 4 Ph.D. thesis Ongoing: 3 M.Sc. Thesis completed:9

Publications:

1. Publications from TIET, Patiala:
   1. Combining the Non-Natural Activity of Lipase and Electrocatalysis in One Pot: Sustainable and Regioselective Synthesis of C-3 Alkylated Oxindoles, Kirti Singh, Vikas Tyagi*, ChemCatChem, 2024, just accepted.
   2. Investigation of electrocatalytic oxidative coupling of arylamines for the selective synthesis of azo aromatics, Pooja Soam, Vikas Tyagi*, The Journal of Organic Chemistry, 2024, DOI: 10.1021/acs.joc.4c01384.
   3. Palladium-catalyzed isocyanide insertion into the remotely activated N-H bond of 3- (phenylhydrazono)oxindoles: Facile access to indole-N-carboxamide derivatives, Pooja Soam, Debasish Mandal, Vikas Tyagi*, Eur. J. Org. Chem., 2024, e202400439.
   4. Enzymatic synthesis of 3-hydroxy bisindoles and further C-3 sulfenylation via combining a carbocatalytic approach in the same pot, Priya Kamboj, Mahipal Bhardwaj, Pooja Sahu, Priyanka Bajaj, Vikas Tyagi*, ChemistrySelect, 2024, 9, e202304826.
   5. A decade update on the promiscuity of α-amylase in organic synthesis, Sunil Dutt, Abinash Mohapatra, Shashi Pandey, Vikas Tyagi*, Tetrahedron, 2024, 155, 133905.
   6. Experimental and computational investigation of the α-amylase catalyzed Friedel-Crafts reaction of isatin to access symmetrical and unsymmetrical 3,3,3-trisindoles, Priya Kamboj, Abinash Mohapatra, Debasish Mandal, Vikas Tyagi*, Org. Biomol. Chem., 2024, 22, 1839-1849.
   7. Enzymatic synthesis of indole-based imidazopyridine using α-amylase, Priya Kamboj, Vikas Tyagi*, ChemBioChem, 2024, e202300824.
   8. Synthesis of N-fused polycyclic indoles via a Pd-catalyzed multicomponent cascade reaction consisting of an amide-directed [3+1+1] annulation reaction of 3-diazo oxindole and isocyanides, Pooja Soam, Debasish Mandal, Vikas Tyagi*, New J. Chem., 2024, 48, 2639-2648.
   9. Graphene oxide-catalyzed carbene-transfer reaction in water: a highly "green" and selective approach to access 3,3',3"-trisindoles, Priya Kamboj, Vikas Tyagi*, Green Chem., 2024, 26, 1990- 1999.
   10. Design and preparation of a bifunctional nanobiohybrid catalyst by combining palladium and α- amylase enzyme: application in one-pot chemoenzymatic catalysis, Parmjeet Kaur, Vikas Tyagi*, ChemNanoMat, 2023, e202300441.
   11. A recent update on the environment friendly methodologies to synthesize bis(indolyl)methane and 3,3-di(3-indolyl)-2-indolone derivatives, Priya Kamboj, Vikas Tyagi*, Tetrahedron, 2023, 148, 133679.
   12. Recent advances in lipase catalyzed multicomponent reactions to synthesize N- heterocycles, Meenakshi Budhiraja, Amjad Ali, Vikas Tyagi*, Asian J. Org. Chem., 2023, 12, e202300427.
   13. Divergent and Selective Synthesis of 3-Alkylidene Oxindoles Using Pd-Catalyzed Multicomponent Reaction Pooja Soam, Debasish Mandal, and Vikas Tyagi*, The Journal of Organic Chemistry, 2023, 88, 11023-11035.
   14. Enzyme-catalyzed addition of diazo compounds to in-situ generated imines, Priya kamboj, Vikas Tyagi*, Tetrahedron, 2023, 137, 133389.
   15. Construction of bis-indole derivatives using α-amylase enzyme: Application in the gram-scale synthesis of bis-indole containing bioactive molecules, Priya kamboj, Vikas Tyagi*, Asian J. Org. Chem., 2023, e202200669.
   16. Construction of a bifunctional Pd(0)-CALB@SiO2 hybrid catalyst for the synthesis and arylation of imidazo[1,2-a]pyridine in one-pot, Meenakshi Budhiraja, Amjad Ali, Vikas Tyagi*, European J. Org. Chem., 2023, e202201426.
   17. Synthesis and substrate controlled modification of β-aminocarbonyls using α-amylase enzyme and Pd-catalyst in one-Pot, Sunil Dutt, Vikas Tyagi*, Biocatal. Biotransformation., 2023, DOI: 10.1080/10242422.2023.2188994.
   18. Production of a recyclable nanobiocatalyst to synthesize quinazolinone derivatives, Meenakshi Budhiraja, Bhupendra Chudasama, Amjad Ali, Vikas Tyagi*, RSC Advances, 2022, 12, 31734.
   19. First biocatalytic synthesis of piperidine derivatives via an immobilized lipase-catalyzed multicomponent reaction, Meenakshi Budhiraja, Amjad Ali, Vikas Tyagi*, New J. Chem., 2022, 46, 4837-4849.
   20. Rhodium-catalyzed Cascade Reactions using Diazo Compounds as a Carbene Precursor to Construct Diverse Heterocycles, Pooja Soam, Priya Kamboj, Vikas Tyagi*, Asian J. Org. Chem., 2021, e2021005.
   21. Biocatalytic synthesis of quinoline derivatives via α-amylase catalysed one-pot domino aza- Michael/Aldol/aromatization reactions, Sunil Dutt, Vikas Tyagi*, Tetrahedron letter, 2021, 87, 153527.
   22. A Pd-catalyzed one-pot cascade consisting of C–C/C–O/N–N bond formation to access benzoxazine fused 1,2,3-triazoles, Pooja Soam, Hashmita Gaba, Debasish Mandal and Vikas Tyagi, Organic & Biomolecular Chemistry, 2021, 19, 9936-9945.
   23. Recent Advances in Iron-Catalyzed Chemical and Enzymatic Carbene-Transfer Reactions, Parmjeet Kaur, Vikas Tyagi*, Adv. Synth. Catal., 2021, 363, 877-905.
   24. First biocatalytic Groebke-Blackburn-Bienayme reaction to synthesize-imidazo[1,2-a]pyridine derivatives using lipase enzyme, Meenakshi Budhiraja, Rajesh Kondabala, Amjad Ali, Vikas Tyagi*, Tetrahedron, 2020, 76, 131643.
   25. Biocatalytic Aza‐Michael Addition of Aromatic Amines to Enone Using α‐Amylase in Water, Sunil Dutt, Vanshita Goel, Neha Garg, Diptiman Choudhury, Dibyendu Mallick, Vikas Tyagi*, Adv. Synth. Catal., 2020, 362, 858-866.
   26. Base-Mediated Reductive Coupling of Indole-3-tosylhydrazone with Thiols/Boronic Acids: Facile Synthesis of 3-(phenylthio)methyl/benzyl Indole Derivatives, Imran Khan, Aanchal Sharma, Priya Kamboj, Banibrata Maity, and Vikas Tyagi, ChemistrySelect, 2020, 5, 591 –600
   27. Experimental and Computational Insights into the Water‐Mediated Decomposition of N‐ Sulfonylhydrazones: A Catalyst‐Free Synthesis of γ‐Keto/Nitrile Sulfones, Shagun Goyal, Meenakshi Budhiraja, Debasish Mandal, Vikas Tyagi*, Asian J. Org. Chem., 2020, 9, 251-258.
   28. CuI-catalyzed highly regioselective C-H functionalization of indoles using indole-3- tosylhydrazons as carbene precursor: An efficient synthesis of 3,3-bis(indolyl)methane derivatives, Priya kamboj, Sunil Dutt, Sourav Chakroborty, Vikas Tyagi*, Tetrahedron letter, 2019, 60, 151162.
   29. Temperature-controlled synthesis of N-acyl anthranilamides and quinazoline-4- ones via Pd- catalysed cascade consisting of isocyanide insertion, Irfan Khan, Jaybir Singh, Imran Khan Sunil Dutt, Shahnawaz Khan, Vikas Tyagi*, Arkivoc, 2019,5, 279-291.

2. Publication from Postdoctoral Research work
   1. Application of a MYC degradation screen identifies sensitivity to CDK9 inhibitors in KRAS- mutant pancreatic cancer, Devon R. Blake1, Angelina V. Vaseva, Richard G. Hodge, McKenzie P. Kline, Thomas S. K. Gilbert, Vikas Tyagi, Daowei Huang, Gabrielle C. Whiten, Jacob E. Larson, Xiaodong Wang, Kenneth H. Pearce, Laura E. Herring, Lee M. Graves, Stephen V. Frye, Michael J. Emanuele, Adrienne D. Cox, and Channing J. Der, Science Signaling, 2019, 12, 7259.
   2. Myoglobin-catalyzed C-H functionalization of unprotected indoles, David A. Vargas, Antonio Tinoco, Vikas Tyagi, and Rudi Fasan, Angew. Chem. Int. ed., 2018, 57, 9911-9915.
   3. Use of Protein Kinase–Focused Compound Libraries for the Discovery of New Inositol Phosphate Kinase Inhibitors, Ana C. Puhl-Rubio, Michael A. Stashko, Huanchen Wang, P. Brian Hardy, Vikas Tyagi, Bing Li, Xiaodong Wang, Dmitri Kireev, Henning J. Jessen, Stephen V. Frye, Stephen B. Shears and Kenneth H. Pearce, SLAS Discovery, 2018, 1-7.
   4. Highly diastereo- and enantioselective synthesis of trifluoromethyl-substituted cyclopropanes via myoglobin-catalyzed transfer of trifluoromethylcarbene, Antonio Tinoco, Viktoria Steck, Vikas Tyagi, and Rudi Fasan, Journal of the American Chemical Society, 2017, 139, 5293-5296.
   5. Gram-scale synthesis of chiral cyclopropane-containing drugs using engineered myoglobin catalysts with complementary stereoselectivity, Priyanka Bajaj, Gopeekrishnan Sreenilayam, Vikas

Tyagi and Rudi Fasan, Angew. Chem. Int. ed., 2016, 55, 16110-16114.

2. 6.       Biocatalytic synthesis of allylic and allenyl sulfides via a myoglobin-catalyzed Doyle-Kirmse reaction, Vikas Tyagi, Gopeekrishnan Sreenilayam, Priyanka Bajaj, Antonio Tinoco and Rudi Fasan, Angew. Chem. Int. ed., 2016, 55, 13562-13566.
   7. Chemoenzymatic synthesis and antileukemic activity of novel C9- and C14-functionalized parthenolide analogs, Vikas Tyagi, Hanan Alwaseem, Kristen M. O’Dwyer, Jessica Ponder, Qi Ying Li a, Craig T. Jordan, and Rudi Fasan, Bioorganic and Medicinal Chemistry, 2016, 24, 3876–3886.
   8. Myoglobin-catalyzed olefination of aryl aldehydes, Vikas Tyagi, and Rudi Fasan, Angew. Chem. Int. ed., 2016, 55, 2512–2516.
   9. Intermolecular carbene S-H insertion catalysed by engineered myoglobin-based catalysts, Vikas Tyagi, Rachel B. Bonn, and Rudi Fasan, Chemical Science, 2015, 6, 2488-2494.
   10. Highly diastereo- and enantioselective olefin cyclopropanation via engineered myoglobin- based catalysts Melanie Bordeaux*, Vikas Tyagi*, and Rudi Fasan, Angew. Chem. Int. ed., 2015, 54, 1744- 1748.
3. Publication from Ph.D. Research work:

11. Diversity-oriented reconstruction of primitive diketopiperazine-fused tetrahydro-b carboline ring systems via Pictet–Spengler/Ugi-4CR/deprotection-cyclization reactions, Irfan Khan, Shahnawaz Khan, Vikas Tyagi, Pradeep Singh Chouhan and Prem M. S. Chauhan, RSC Advances, 2015, 5, 10271.
12. A natural product inspired hybrid approach towards the synthesis of novel pentamidines based scaffolds as potential anti-parasitic agents, Vikas Tyagi, Shahnawaz Khan, Rahul Shivahare, Khushboo Srivastava, Suman Gupta, Saqib Kidwai, Kumkum Srivastava, S. K. Puri and Prem M. S. Chauhana, Bioorganic & Medicinal Chemistry Letters, 2013, 23, 291–295.
13. Facile synthesis of diverse isoindolinone derivatives via Ugi-4CR followed by Cu-catalyzed deamidative C(sp2)–C(sp3) coupling, Vikas Tyagi, Shahnawaz Khan and Prem M. S. Chauhan, Tetrahedron Letter, 2013, 54, 1279-1284.
14. A simple and efficient microwave-assisted synthesis of substituted isoindolinone derivatives via ligand-free Pd-catalyzed tandem C-C/C-N coupling reaction, Vikas Tyagi, Shahnawaz Khan and Prem M. S. Chauhan, Synlett, 2013, 24, 0645–0651.
15.       Ugi 4-CR with tandem deprotection, cyclization and Pictet-Spengler reaction: A concise route to N-fused polycyclic indolediketopiperazine alkaloid analogue, Vikas Tyagi, Shahnawaz Khan, and Prem M. S. Chauhan, Synlett, 2013, 24, 1291-1297.
16. An expedient base mediated desulfitative dimethylamination, oxidation, and etherification of the 2-(methylthio)-1H-imidazole-5(4H)-one scaffolds using N, N-dimethylformamide and aliphatic alcohol,Shahnawaz Khan, Vikas Tyagi, Rohit Mahar, Vikas Bajpai, Brijesh Kumar and Prem M. S. Chauhan, Synthesis, 2013, 45, 2405-2412.
17. Skeletal Diverse Synthesis of N-Fused Polycyclic Heterocycles via the Sequence of Ugi- type MCR and CuI Catalyzed Coupling/Tandem Pictet-Spengler Reaction, Vikas Tyagi, Shahnawaz Khan, Vikas Bajpai, Harsh M. Gauniyal, Brijesh Kumar and Prem M. S. Chauhan, Journal of Organic Chemistry, 2012, 77, 1414–1421.
18. A ligand free Pd-catalyzed cascade reaction: An access to the highly diverse Isoquinolin- (2H)-one derivatives using isocyanide and Ugi-4CR synthesize amide precursors, Vikas Tyagi, Shahnawaz Khan, Archana Giri, Harsh M. Gauniyal, B. Sridhar and Prem M. S. Chauhan, Organic letter, 2012, 14, 3126-3139.

Invited lectures:

2024: Delivered invited talk on “” at International Conference organized by Department of Chemistry, Dibrugarh University, Assam, India.