Dr. Mily Bhattacharya
Assistant Professor
Specialization
Biophysical chemistry, Spectroscopy, Protein and peptide-based supramolecular chemistry, Nanoscale biophysics, Protein-nanoparticle interactions
mily.bhattacharya@thapar.edu
Biophysical chemistry, Spectroscopy, Protein and peptide-based supramolecular chemistry, Nanoscale biophysics, Protein-nanoparticle interactions
milybh@gmail.com
(0175) 239-3443
Education and Training:
Professional Affiliations:
School of Chemistry and Biochemistry, Thapar University, Patiala
School of Chemistry and Biochemistry, Thapar University, Patiala
Indian Institute of Science Education and Research (IISER) Mohali, Punjab
Area of research: Protein-nanoparticle interactions, Nanophotonics of protein amyloids.
Indian Institute of Science Education and Research (IISER) Mohali, Punjab
Area of research: Biophysical chemistry of peptides & proteins and nanoscale biophysics.
Indian Institute of Science Education and Research (IISER) Mohali, Punjab
Area of research: Biophysical chemistry of protein aggregation.
Department of Molecular Biology, The Scripps Research Institute, California, USA.
Area of research: Synthesis of HIV protease inhibitors and precursors of catalytic antibodies.
Department of Inorganic & Physical Chemistry, Indian Institute of Science (IISc), Bangalore.
Advisor: Prof. Puspendu K. Das
Title of thesis: Quadratic nonlinearity in covalently and non-covalently linked molecules in solution
Area of research: Organic supramolecular Chemistry, Materials Chemistry and Nonlinear Optics.
List of Publications:
“Salt-induced dissolution of protein aggregates”, D. Singla and M. Bhattacharya* J. Phys. Chem. B 2022, 126, 8760-8770. (* Corresponding Author)
“The protein–surfactant stoichiometry governs the conformational switching and amyloid nucleation kinetics of tau K18”, J. Kaur, A. Giri and M. Bhattacharya* Euro. Biophys. J. 2020, 49, 425-434. (* Corresponding Author)
“Unraveling the mechanism of functional and pathological amyloid formation from intrinsically disordered proteins”, M. Bhattacharya*, A. Giri, J. Kaur, P. Dogra, S. Mukhopadhyay Biophys. J. 2020, 118 (3), 59a (Abstract).
“Proton-Induced Switching of an Intrinsically Disordered Domain of a Melanosomal Protein into a Polymorphic Functional Amyloid”, P Dogra, SS Roy, M Bhattacharya, SS Prabhu, S Mukhopadhyay
Biophys. J. 2018, 114 (3), 590a (Abstract).
“pH-responsive mechanistic switch regulates the formation of dendritic and fibrillar nanostructures of a functional amyloid”, P. Dogra, M. Bhattacharya* and S. Mukhopadhyay* J. Phys. Chem. B 2017, 121, 412-419. (* Corresponding Author)
“Water rearrangements upon disorder-to-order amyloid transition”, S. Arya, A.K. Singh, T. Khan, M. Bhattacharya, A. Datta, and S. Mukhopadhyay J. Phys. Chem. Lett. 2016, 7, 4105-4110.
“Direct observation of the intrinsic backbone torsional mobility of disordered proteins by fluorescence depolarization kinetics”, N. Jain, D. Narang, K. Bhasne, V. Dalal, S. Arya, M. Bhattacharya, and S. Mukhopadhyay Biophys. J. 2016, 111, 768-774.
“Self-assembly of ovalbumin amyloid pores: Effects on membrane permeabilization, dipole potential and bilayer fluidity”, M. Bhattacharya*, and P. Dogra Langmuir 2015, 31, 8911-8922.
(* Corresponding Author)
“Appearance of annular ring-like intermediates during amyloid fibril formation from human serum albumin”, S. Arya, A. Kumari, V. Dalal, M. Bhattacharya*, and S. Mukhopadhyay* Phys. Chem. Chem. Phys. 2015, 17, 22862-22871. (* Corresponding Author)
“Conformational switching and nanoscale assembly of human prion protein into polymorphic amyloids via structurally labile oligomers”, V. Dalal, S. Arya, M. Bhattacharya, and S. Mukhopadhyay Biochemistry 2015, 54, 7505-7513.
“Nanophotonics of protein amyloids”, M. Bhattacharya*, and S. Mukhopadhyay* Nanophotonics 2014, 3, 51-59. (* Corresponding Author)
“Nanoscale Assembly of Proteins into Amyloid Oligomers, Pores and Fibrils”, M. Bhattacharya, N. Jain, P. Dogra, V. Dalal, D. Narang, P. K Sharma, S. Samai, S. Mukhopadhyay Biophys. J. 2014, 106 (2), 683a (Abstract).
“Nanoscopic amyloid pores formed via stepwise protein assembly”, M. Bhattacharya*, N. Jain, P. Dogra, S. Samai and S. Mukhopadhyay* J. Phys. Chem. Lett. 2013, 4, 480-485.
(* Corresponding Author)
“Structural and dynamical insights into the molten-globule form of Ovalbumin”, M. Bhattacharya* and S. Mukhopadhyay* J. Phys. Chem. B 2012, 116, 520-531.
(* Corresponding Author)
“Nanoscale fluorescence imaging of single amyloid fibrils”, V. Dalal*, M. Bhattacharya*, D. Narang, P.K. Sharma, and S. Mukhopadhyay J. Phys. Chem. Lett. 2012, 3, 1783-1787. (*Equal Contribution)
“Chain collapse of an amyloidogenic intrinsically disordered protein”, N. Jain*, M. Bhattacharya* and S. Mukhopadhyay Biophys. J. 2011, 101, 1720-1729. (*Equal Contribution)
Featured as a ‘Must Read’ article in the Faculty of 1000 (http://f1000.com/13409028)
“Insights into the mechanism of aggregation and fibril formation from Bovine Serum Albumin”, M. Bhattacharya, N. Jain and S. Mukhopadhyay J. Phys. Chem. B 2011, 115, 4195–4205.
“pH-induced conformational isomerization of bovine serum albumin studied by extrinsic and intrinsic protein fluorescence”, M. Bhattacharya, N. Jain, K. Bhasne, V. Kumari and S. Mukhopadhyay J. Fluorescence 2011, 21, 1083-1090.
“Kinetics of surfactant-induced aggregation of lysozyme studied by fluorescence spectroscopy” N. Jain, M. Bhattacharya and S. Mukhopadhyay J. Fluorescence 2011, 21, 615-625.
“Quadratic nonlinearity of one- and two-electron oxidized metalloporphyrins and its switching in solution”, A. Wahab, M. Bhattacharya, S.Ghosh, A.G. Samuelson and P. K. Das. J. Phys. Chem. B 2008, 112, 2842-2847.
“Enhancement of quadratic nonlinearity via multiple hydrogen bonded supramolecular complex formation”, M. Bhattacharya, A.G. Samuelson and P. K. Das J. Phys. Chem. B 2007, 111, 7122-7126.
“Second order nonlinearity in oligoamides”, M. Bhattacharya and P. K. Das Synth. Met. 2005, 155, 389-392.
“Synthesis and nonlinear optical properties of some donor-acceptor oxadiazoles”, S. H. Mashraqui, R. S. Kenny, S. G. Ghadigaonkar, A. Krishnan, M. Bhattacharya and P. K. Das, Opt. Mater. 2004, 27, 257-260.
Teaching Activities:
Book chapters
"Studying protein misfolding and aggregation using fluorescence spectroscopy" M. Bhattacharya, and S. Mukhopadhyay Reviews in Fluorescence, 2015 Chris D. Geddes (Ed.) Vol. 8, Springer International Publishing, Switzerland.
“Nonlinear Optical Properties of Organometallic and Metalloorganic Compounds”, M. Bhattacharya, P. K. Das and A. G. Samuelson, in Handbook of Organic Electronics and Photonics, 2008 H. S. Nalwa (Ed.) Vol. 2, American Scientific Publishers, California, USA.
Oral and Poster Presentations:
Awards/Honours/Fellowships:
Sponsored Research Projects:
Other Professional Activities: